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Painful gastric distension and belching may be caused by the liberation of large volumes of oxygen in the stomach. Ingestion of hydrogen peroxide may cause irritation of the gastrointestinal tract with nausea, vomiting, haematemesis and foaming at the mouth the foam may obstruct the respiratory tract or result in pulmonary aspiration. Hydrogen peroxide can also exert a direct cytotoxic effect via lipid peroxidation. In addition, intravascular foaming following absorption can seriously impede right ventricular output and produce complete loss of cardiac output. Rapid generation of oxygen in closed body cavities can also cause mechanical distension and there is potential for the rupture of the hollow viscus secondary to oxygen liberation. The mechanism of CNS damage is thought to be arterial gas embolisation with subsequent brain infarction. Where the amount of oxygen evolved exceeds its maximum solubility in blood, venous or arterial gas embolism may occur. Ingestion of concentrated (>35%) hydrogen peroxide can also result in the generation of substantial volumes of oxygen. Concentrated hydrogen peroxide is caustic and exposure may result in local tissue damage. Hydrogen peroxide causes toxicity via three main mechanisms: corrosive damage, oxygen gas formation and lipid peroxidation. Hydrogen peroxide has been employed medicinally for wound irrigation and for the sterilisation of ophthalmic and endoscopic instruments.
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In industry, the principal use of hydrogen peroxide is as a bleaching agent in the manufacture of paper and pulp.
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Hydrogen peroxide is an oxidising agent that is used in a number of household products, including general-purpose disinfectants, chlorine-free bleaches, fabric stain removers, contact lens disinfectants and hair dyes, and it is a component of some tooth whitening products.